Metabolic pathways mediating insulin resistance and gestational diabetes mellitus discovered by high-dimensional systematic Mendelian randomization
These results indicated that targeting specific metabolic pathways through dietary intervention is worth exploring as a possible GDM prevention approach, and hdsMR is more efficient in finding causal mediating metabolic pathways than traditional MR methods.
Authors
- Dandan Yan (ORCID: https://orcid.org/0000-0001-9799-3325)
- Xiangtian Yu (ORCID: https://orcid.org/0000-0002-9571-3446)
- Weituo Zhang
- Yun-Ting Huang (ORCID: https://orcid.org/0000-0001-7017-9198)
- Wei Chen (ORCID: https://orcid.org/0000-0003-4560-4599)
- Cheng Hu (ORCID: https://orcid.org/0000-0003-4314-2386)
- Suna Wang (ORCID: https://orcid.org/0000-0002-3791-1786)
- Jingyi Guo (ORCID: https://orcid.org/0000-0002-9514-7157)
- Tao Zeng (ORCID: https://orcid.org/0000-0002-3349-0291)
- Jing Ying Yan (ORCID: https://orcid.org/0000-0001-8265-6270)
- Rong Zhang (ORCID: https://orcid.org/0000-0003-3057-0170)
- Xiaohui Feng (ORCID: https://orcid.org/0000-0002-8931-9629)
- Mingjuan Luo
- Sheng Li (ORCID: https://orcid.org/0000-0003-4070-7345)
Institutions
- Shanghai Jiao Tong University (CN)
- University of Hong Kong - Shenzhen Hospital (CN)
- Shanghai Sixth People's Hospital (CN)
- University of Hong Kong (HK)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1186/s12933-025-02746-0
- Citations
- 1
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- National Natural Science Foundation of China
- Shanghai Jiao Tong University
- School of Medicine, Shanghai Jiao Tong University
- National Key Research and Development Program of China
- Fundamental Research Funds for the Central Universities