Knockdown of eIF3a alleviates pulmonary arterial hypertension by inhibiting endothelial-to-mesenchymal transition via TGFβ1/SMAD pathway
Knockdown of eIF3a inhibited EndMT in PAECs regulating TGFβ1/SMAD signaling pathway, significantly alleviated the changes of RVSP, RVH and vascular remodeling in MCT-induced PAH rats, eIF3a may be a promising and novel therapeutic target for the treatment of PAH.
Authors
- Tao Huang (ORCID: https://orcid.org/0000-0001-9702-4217)
- Jingtian Li (ORCID: https://orcid.org/0000-0001-6772-807X)
- Wanpeng Qi
- Qiuhong Jiao (ORCID: https://orcid.org/0000-0002-5603-9698)
- Yudan Zhao (ORCID: https://orcid.org/0009-0002-8012-0637)
- Xiaohong Liu (ORCID: https://orcid.org/0000-0003-4931-8370)
- Yuying Wang (ORCID: https://orcid.org/0009-0000-3482-4110)
- Tao Wang (ORCID: https://orcid.org/0000-0002-4954-3546)
- Longwu Xu
- Xiufeng Xu (ORCID: https://orcid.org/0000-0003-3885-3271)
- Jie Hao (ORCID: https://orcid.org/0000-0002-0273-8047)
- Limin Qin
- Shulan Pang
Institutions
- Weifang Medical University (CN)
- Second Hospital of Shandong University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1186/s12967-025-06505-3
- Citations
- 8
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 12.15