ESPN activates ZEB1-mediated EMT through the PI3K/AKT/mTOR axis to promote osteosarcoma metastasis
Our findings reveal a previously unrecognized function of ESPN in OS, closely linked with EMT and cancer metastasis progression. Targeting ESPN may represent a potential therapeutic approach for patients with OS.
Authors
- Yuqing Jiang (ORCID: https://orcid.org/0000-0002-4202-3038)
- Zhengyi Sun (ORCID: https://orcid.org/0000-0001-6269-4691)
- Yifei Shen (ORCID: https://orcid.org/0000-0002-1401-7183)
- Dong Zhou (ORCID: https://orcid.org/0000-0003-1981-8745)
- Hongyu Wu (ORCID: https://orcid.org/0000-0003-1278-4183)
- Xiaofei Wang (ORCID: https://orcid.org/0000-0001-8953-9050)
- Ru Zhou (ORCID: https://orcid.org/0000-0002-3502-9861)
- You Hao (ORCID: https://orcid.org/0000-0001-6603-966X)
- Xiuchen Yuan
Institutions
- Changzhou No.2 People's Hospital (CN)
- Hangzhou Children's Hospital (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1186/s12967-025-06500-8
- Citations
- 2
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- National Natural Science Foundation of China-Xinjiang Joint Fund