Cocultured amniotic stem cells and cardiomyocytes in a 3-D acellular heart patch reduce the infarct size and left ventricle remodeling: promote angiogenesis in a porcine acute myocardial infarction model
Epicardial transplantation of an acellular amniotic heart patch cocultured with cardiomyocytes and pASCs demonstrated superior cardiomyogenesis after eight weeks compared to pASC transplantation alone or control conditions. The coculture system was found to enhance the cardiac regeneration process, as evidenced by improved RWMA, distinct sarcomeric organization, reduced fibrotic scarring, and lower apoptotic gene expression.
Authors
- Gunanti Gunanti (ORCID: https://orcid.org/0009-0007-7665-5264)
- Tri Wisesa Soetisna (ORCID: https://orcid.org/0000-0002-7428-3600)
- Normalina Sandora (ORCID: https://orcid.org/0000-0002-2332-9605)
- Muhammad Arza Putra (ORCID: https://orcid.org/0000-0002-1584-0403)
- Deni Noviana (ORCID: https://orcid.org/0000-0001-9496-0130)
- Tyas Rahmah Kusuma (ORCID: https://orcid.org/0009-0006-3663-2781)
- Supomo Supomo (ORCID: https://orcid.org/0000-0002-2210-5466)
- Nur Amalina Fitria (ORCID: https://orcid.org/0000-0001-8163-9604)
- Idrus Alwi (ORCID: https://orcid.org/0000-0001-5662-8743)
- Pribadi Wiranda Busro (ORCID: https://orcid.org/0000-0003-4537-720X)
- Benati Karimah
Institutions
- Universitas Gadjah Mada (ID)
- IPB University (ID)
- University of Indonesia (ID)
- Pembuluh Darah Harapan Kita (ID)
Publication Details
- Journal
- Journal of Cardiothoracic Surgery
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1186/s13019-025-03453-3
- Citations
- 1
- Primary Topic
- Congenital heart defects research
- Type
- article
- Field-Weighted Citation Impact
- 0.81