Life’s Essential 8 cardiovascular health, cardiovascular-kidney-metabolic syndrome stages, and incident cardiovascular events: a nationwide 10-year prospective cohort study in China
The study indicated that cardiovascular-kidney-metabolic stage was associated with cardiovascular events, and optimal cardiovascular health could attenuate this risk. Health factor contributed predominantly at the early-stage, whereas health behavior exhibited consistent and slightly increased contribution along the spectrum. These findings support the utility of cardiovascular-kidney-metabolic construct and highlight the importance of target health improvement based on LE 8 framework.
Authors
- Yufang Bi (ORCID: https://orcid.org/0000-0002-4829-5915)
- Jiajun Zhao (ORCID: https://orcid.org/0000-0003-3267-9292)
- Yiming Mu (ORCID: https://orcid.org/0000-0002-3344-3540)
- Jieli Lu (ORCID: https://orcid.org/0000-0003-1317-0896)
- Zuojie Luo (ORCID: https://orcid.org/0000-0003-2377-6357)
- Hong Lin (ORCID: https://orcid.org/0000-0001-8973-1819)
- Xuejiang Gu (ORCID: https://orcid.org/0000-0002-7629-7627)
- Xuefeng Yu (ORCID: https://orcid.org/0000-0003-3961-9321)
- Yi Ding (ORCID: https://orcid.org/0000-0002-2158-3108)
- Yingfen Qin (ORCID: https://orcid.org/0000-0002-8456-1678)
- Lixin Shi (ORCID: https://orcid.org/0000-0002-0389-2732)
- Xinguo Hou (ORCID: https://orcid.org/0000-0003-2045-1290)
- Zhiyun Zhao (ORCID: https://orcid.org/0000-0001-5950-2732)
- Guijun Qin (ORCID: https://orcid.org/0000-0002-2503-7534)
- Tiange Wang (ORCID: https://orcid.org/0000-0003-0723-489X)
- Yu Xu (ORCID: https://orcid.org/0000-0002-0574-1460)
- Shuangyuan Wang (ORCID: https://orcid.org/0000-0002-5664-3086)
- Jie Zheng (ORCID: https://orcid.org/0000-0002-6623-6839)
- Xulei Tang
- Feixia Shen (ORCID: https://orcid.org/0000-0002-0778-0041)
- Youmin Wang (ORCID: https://orcid.org/0000-0003-0964-9677)
- Tianshu Zeng (ORCID: https://orcid.org/0000-0001-9171-7151)
- Qing Su (ORCID: https://orcid.org/0000-0001-7945-1258)
- Zhengnan Gao (ORCID: https://orcid.org/0000-0002-0077-8758)
- Chao Liu (ORCID: https://orcid.org/0000-0002-5323-6733)
- Weiqing Wang (ORCID: https://orcid.org/0000-0001-6027-3084)
- Gang Chen
- Lulu Chen (ORCID: https://orcid.org/0000-0001-9621-9231)
- Qiang Li (ORCID: https://orcid.org/0000-0002-9815-4432)
- Yu‐Hong Chen (ORCID: https://orcid.org/0009-0009-8356-0153)
- Qin Wan (ORCID: https://orcid.org/0000-0001-7765-1416)
- Lixia Chen (ORCID: https://orcid.org/0000-0003-2196-1428)
- Yan Li (ORCID: https://orcid.org/0000-0001-7609-2683)
- Mian Li (ORCID: https://orcid.org/0000-0001-6514-2729)
- Hong Qiao (ORCID: https://orcid.org/0000-0002-4360-5881)
- Yanan Huo (ORCID: https://orcid.org/0000-0002-9774-6698)
- Huacong Deng (ORCID: https://orcid.org/0000-0002-8053-7056)
- Guang Ning (ORCID: https://orcid.org/0000-0002-9728-2897)
- Guixia Wang (ORCID: https://orcid.org/0000-0001-9885-225X)
- Yinfei Zhang
- Min Xu (ORCID: https://orcid.org/0000-0003-4464-453X)
- Tao Yang
- Ruying Hu
- Zhen Ye (ORCID: https://orcid.org/0009-0000-8766-8262)
- Shengli Wu
Institutions
- Fujian Medical University (CN)
- Nanchang University (CN)
- Shandong University (CN)
- Harbin Medical University (CN)
- Sun Yat-sen University (CN)
- Guangxi Medical University (CN)
- Shanghai Jiao Tong University (CN)
- Jilin University (CN)
- Anhui Medical University (CN)
- National Health and Family Planning Commission (CN)
- Wenzhou Medical University (CN)
- XinHua Hospital (CN)
- Ruijin Hospital (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
- Jiading District Central Hospital (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Dalian Municipal Central Hospital (CN)
- Jiangxi Provincial People's Hospital (CN)
- Shandong Provincial Hospital (CN)
- First Hospital of Jilin University (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
- Wuhan Union Hospital (CN)
- The Affiliated Yongchuan Hospital of Chongqing Medical University (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
- Zhejiang Center for Disease Control and Prevention (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Fujian Provincial Hospital (CN)
- Karamay Central Hospital (CN)
- Shanghai Institute of Hematology (CN)
- Jiangsu Province Hospital (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
- Tongji Hospital (CN)
- Qilu Hospital of Shandong University (CN)
- First Hospital of Lanzhou University (CN)
- Huazhong University of Science and Technology (CN)
- Lanzhou University (CN)
- Nanjing Medical University (CN)
- Chongqing Medical University (CN)
Publication Details
- Journal
- Cardiovascular Diabetology
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1186/s12933-025-02735-3
- Citations
- 9
- Primary Topic
- Cardiovascular Health and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 12.49
Funders
- Science and Technology Commission of Shanghai Municipality
- Shanghai Municipal People's Government
- National Key Research and Development Program of China