Prostate cancer clinicopathological presentation in South-East Africa during the 2010 decade
Prostate cancer is the leading cause of cancer-associated death among men across Sub-Saharan Africa, with Southern and East Africa ranking first and fifth globally. However, lack of coordinated national cancer registries has biased data toward single-sourced, averaged, or model estimates. Here, our retrospective study included 8634 South-East African patients diagnosed between 2010 and 2019, which when compared with 71 694 Black and 322 356 White period-matched American men, were over threefold more likely to present with aggressive disease (International Society of Urological Pathology grade groups ≥4: 45.38% vs 21.22% and 21.05%; prostate-specific antigen ≥20 ng/mL: 62.04% vs 17.29% and 11.17%, respectively; all 2-sided P < .0001). East over Southern African men are 1.5 times more likely to present with advanced disease, however, age was not a confounder. Supporting prostate cancer as a major health concern for Africa, our data suggest underestimation in East Africa, while highlighting the need for accurate monitoring, increased awareness, and tailored screening criteria.
Authors
- Ikenna Madueke (ORCID: https://orcid.org/0000-0001-9319-4278)
- Pavlo Lutsik (ORCID: https://orcid.org/0000-0001-9383-8555)
- Shingai B.A. Mutambirwa (ORCID: https://orcid.org/0000-0003-1414-0218)
- David C. Wedge (ORCID: https://orcid.org/0000-0002-7572-3196)
- Meshack Bida (ORCID: https://orcid.org/0000-0002-2282-1155)
- Willis Oyieko
- Sean Mark Patrick (ORCID: https://orcid.org/0000-0002-0364-0068)
- Rosalind A. Eeles (ORCID: https://orcid.org/0000-0002-3698-6241)
- I.E.J. Barnhoorn (ORCID: https://orcid.org/0000-0002-6635-304X)
- Pamela X. Y. Soh (ORCID: https://orcid.org/0000-0002-8485-6556)
- Riana Bornman (ORCID: https://orcid.org/0000-0003-3975-2333)
- Daniel M. Moreira (ORCID: https://orcid.org/0000-0003-4517-244X)
- Maria Argos (ORCID: https://orcid.org/0000-0003-4234-252X)
- Vanessa M. Hayes (ORCID: https://orcid.org/0000-0002-4524-7280)
- P M Ngugi
- Joyce Shirinde (ORCID: https://orcid.org/0000-0002-3467-1043)
- Maphuti Tebogo Lebelo (ORCID: https://orcid.org/0000-0002-6377-8261)
- Weerachai Jaratlerdsiri (ORCID: https://orcid.org/0000-0001-9100-1807)
- Gail S. Prins (ORCID: https://orcid.org/0000-0002-9044-4734)
- Melanie Louw (ORCID: https://orcid.org/0000-0002-9827-1225)
- Raymond Campbell (ORCID: https://orcid.org/0000-0003-2254-1556)
- Douglas I. Walker (ORCID: https://orcid.org/0000-0003-2912-398X)
- Massimo F. Loda (ORCID: https://orcid.org/0000-0001-9674-8379)
- Jenna Craddock (ORCID: https://orcid.org/0000-0003-2373-7227)
- Muvhulawa Obida
- Edwin O O Walong
- Micah Oyaro (ORCID: https://orcid.org/0000-0001-5543-9983)
- Daniel S. Brewer (ORCID: https://orcid.org/0000-0003-4753-9794)
- Mulalo B. Radzuma
- Winstar Mokua Ombuki (ORCID: https://orcid.org/0000-0002-5325-2506)
- Tumisang M N Mbeke
- Muriuki Elias Nyaga
- Joan Ndambuki
- Allan Yienya
Institutions
- National Health Laboratory Service (ZA)
- University of Nairobi (KE)
- The University of Sydney (AU)
- University of Manchester (GB)
- University of Illinois Chicago (US)
- Cancer Research UK Manchester Institute (GB)
- East African University (KE)
- NIHR Manchester Biomedical Research Centre (GB)
- Cancer Research UK Manchester Centre
- University of Pretoria (ZA)
Publication Details
- Journal
- JNCI Journal of the National Cancer Institute
- Published
- 2025-05-08
- DOI
- https://doi.org/10.1093/jnci/djaf117
- Citations
- 1
- Primary Topic
- Prostate Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.52