Formation of Neurointerfaces Based on Electrically Conductive Biopolymers by Two-Photon Polymerization Method

Preventing false signals of phantom pain after limb amputation is crucial. The development of neurointerfaces capable of bidirectional information exchange between the brain and external devices, along with long-term use, is a key research priority. The main problem with existing devices lies in the potential formation of scar tissue and the death of adjacent neurons. To address this issue, a polymer composite based on new composition: chitosan, bovine serum albumin, single-walled carbon nanotubes, and Eosin Y, which was created for the fabrication of a neurointerface. A polymer composite of the required shape was formed by two-photon polymerization. In studying its nonlinear optical properties, the new effect of phase self-modulation was discovered, which is observed after exposure to laser radiation prior to the formation of the composite. The time of appearance of diffraction rings was measured. This allowed optimization of laser parameters-scanner speed and intensity. The resulting homogeneous composite exhibited a specific conductivity of 20 mS × cm^-1, sufficient for electrophysiological signal transmission.