LncRNA HOTAIR Interaction With WTAP Promotes m<sup>6</sup>A Methyltransferase Complex Assembly and Posterior Capsule Opacification Formation by Increasing THBS1
LncRNA HOTAIR enhances the assembly of the WTAP/METTL3/METTL14 complex and promotes EMT in LECs by upregulating m6A modification and THBS1 expression. Targeting the HOTAIR/WTAP/THBS1 pathway may prevent or treat PCO.
Authors
- Chenshuang Li (ORCID: https://orcid.org/0000-0001-6331-6983)
- Yan Hong (ORCID: https://orcid.org/0000-0002-0397-4586)
- Xi Chen (ORCID: https://orcid.org/0000-0002-6730-3271)
- Siqi Zhang (ORCID: https://orcid.org/0000-0002-9815-4395)
- Zaoxia Guo
- Chenjun Guo
- Jiankui Li
Institutions
- Northwestern Polytechnical University (CN)
- Northwest University (CN)
- 82th Hospital of Pla (CN)
- Shanxi Eye Hospital (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1167/iovs.66.5.20
- Citations
- 1
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81