Enhanced allergic Eustachian tube response in surfactant protein D knockout mice induced by ovalbumin
SPD plays a critical role in regulating allergic inflammation and protecting ET function. Its deficiency exacerbates OVA-induced inflammation and functional impairment of the ET, while exogenous SPD administration ameliorates tissue inflammation and restores ACNP efficacy. These findings highlight SPD as a therapeutic target for allergic ETD.
Authors
- Hongjun Xiao (ORCID: https://orcid.org/0000-0002-1776-5435)
- Hejie Li (ORCID: https://orcid.org/0000-0002-4851-7194)
- Xiaohua Lian (ORCID: https://orcid.org/0000-0002-3682-2087)
- Shimin Zong (ORCID: https://orcid.org/0009-0004-3709-1599)
- Ting Li (ORCID: https://orcid.org/0009-0009-2967-3237)
- Xuan Yu (ORCID: https://orcid.org/0009-0009-9130-2939)
- Wei Tang (ORCID: https://orcid.org/0000-0002-1990-4558)
- Wenting Yu
Institutions
- Union Hospital (HK)
- Hubei University of Chinese Medicine (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- World Allergy Organization Journal
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1016/j.waojou.2025.101061
- Citations
- 2
- Primary Topic
- Ear Surgery and Otitis Media
- Type
- article
- Field-Weighted Citation Impact
- 3.70
Funders
- National Natural Science Foundation of China
- Huazhong University of Science and Technology
- Tongji University
- Key Technologies Research and Development Program
- National Key Research and Development Program of China
- Tongji Medical College, Huazhong University of Science and Technology