Enhanced B cell and complement cascade gene signatures in patients with neuropsychiatric systemic lupus erythematosus
The clinical heterogeneity of NPSLE appears to be associated with molecular diversity, with certain endotypes or syndromes exhibiting distinct gene signatures. Upregulation of adaptive immune response and complement cascade suggests that complement inhibitors and B cell-targeted therapies could be further explored in NPSLE.
Authors
- Panagiotis Garantziotis
- George Sentis
- Myrto Nikoloudaki
- Katerina Chavatza (ORCID: https://orcid.org/0000-0002-1274-0909)
- Anastasia Filia (ORCID: https://orcid.org/0000-0003-3824-2745)
- Antigone Pieta (ORCID: https://orcid.org/0000-0003-2361-0525)
- Aggelos Banos (ORCID: https://orcid.org/0000-0002-5647-6505)
- Dimitrios T. Boumpas (ORCID: https://orcid.org/0000-0002-9812-4671)
- George K Bertsias (ORCID: https://orcid.org/0000-0001-5299-1406)
- Noemin Kapsala (ORCID: https://orcid.org/0000-0002-6024-8185)
- Dionysis Nikolopoulos (ORCID: https://orcid.org/0000-0002-9894-6966)
- Antonis Fanouriakis (ORCID: https://orcid.org/0000-0003-2696-031X)
- Theodora Manolakou (ORCID: https://orcid.org/0000-0001-5284-6655)
- Sofia Flouda (ORCID: https://orcid.org/0000-0002-5423-5847)
- Ioannis Parodis (ORCID: https://orcid.org/0000-0002-4875-5395)
- Iasonas Kitsios
Institutions
- Karolinska University Hospital (SE)
- University of Crete (GR)
- National and Kapodistrian University of Athens (GR)
- Academy of Athens (GR)
- Universitätsklinikum Erlangen (DE)
- Institute of Molecular Biology and Biotechnology (BG)
Publication Details
- Journal
- Annals of the Rheumatic Diseases
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1016/j.ard.2025.04.006
- Citations
- 6
- Primary Topic
- Systemic Lupus Erythematosus Research
- Type
- article
- Field-Weighted Citation Impact
- 10.01