Fecal Butyrate and Deoxycholic Acid Concentrations Correlate With Mortality in Patients With Liver Disease
Mass spectrometry rapidly identifies patients with low fecal butyrate and DCA concentrations who are at increased risk of 30-day mortality. These findings set the stage for clinical trials of microbiome reconstitution with butyrate and DCA-producing bacterial species.
Authors
- Talha Tanveer
- Matthew A. Odenwald (ORCID: https://orcid.org/0000-0003-1740-6472)
- Michael W. Mullowney (ORCID: https://orcid.org/0000-0002-2884-4307)
- Mary Eugenia Rinella (ORCID: https://orcid.org/0000-0003-0620-9705)
- Anitha Sundararajan (ORCID: https://orcid.org/0000-0001-9550-3644)
- Mary McMillin
- Jessica Little (ORCID: https://orcid.org/0000-0002-8032-1378)
- Amber R. Rose (ORCID: https://orcid.org/0000-0002-1388-0305)
- David Morán (ORCID: https://orcid.org/0000-0001-9344-8602)
- Eric G. Pamer (ORCID: https://orcid.org/0000-0002-6755-9904)
- Huaiying Lin
- Victoria Burgo (ORCID: https://orcid.org/0000-0003-1016-3199)
- Che Woodson
- Nicholas P. Dylla (ORCID: https://orcid.org/0000-0002-8731-5640)
- Christopher Lehmann (ORCID: https://orcid.org/0000-0002-1111-2169)
- Ashley M. Sidebottom (ORCID: https://orcid.org/0000-0002-8670-9090)
- Andrew Aronsohn
- Ramanujam Ramaswamy (ORCID: https://orcid.org/0000-0001-7448-6574)
- Dinanath Sulakhe (ORCID: https://orcid.org/0000-0002-4680-1212)
- Jackelyn Cantoral
- Angelica Moran (ORCID: https://orcid.org/0000-0003-4013-2182)
- Andrea Da Porto (ORCID: https://orcid.org/0000-0001-9995-0169)
- Antonio Bencomo Hernández (ORCID: https://orcid.org/0000-0002-7883-4852)
- Emerald Adler
- Mark D’Souza
- Caroline Jadczak
Institutions
- Chicago Department of Public Health (US)
- University of Chicago (US)
- Duchossois Group (United States) (US)
Publication Details
- Journal
- Gastro Hep Advances
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1016/j.gastha.2025.100695
- Citations
- 3
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- University of Chicago
- Gastro-Intestinal Research Foundation