A novel mechanosensitive stress test in individuals following anterior cruciate ligament reconstruction: A pilot study
The tilt paradigm identified a differential response of a serum mechanosensitive marker (COMP) when testing an ACLR and contralateral knee. There was also a significant relationship between COMP response to tilt walking and the change in knee adduction angle of the ACLR knee. This paradigm could be an aid to provide individual knee biomarker response to a mechanical stress in asymptomatic individuals at risk of developing post-traumatic osteoarthritis at least 2 years post-ACLR.
Authors
- Prakash Jayabalan (ORCID: https://orcid.org/0000-0002-0369-2896)
- Rose Darcy (ORCID: https://orcid.org/0000-0002-2890-5034)
- Levi J. Hargrove (ORCID: https://orcid.org/0000-0002-1705-0050)
- Leah J. Welty (ORCID: https://orcid.org/0000-0002-6096-2274)
- A. Neuville (ORCID: https://orcid.org/0000-0001-7573-9369)
- Thomas J. Schnitzer (ORCID: https://orcid.org/0000-0002-4048-5431)
- Vikram Darbhe
- Vehniah K. Tjong (ORCID: https://orcid.org/0000-0001-9890-8954)
Institutions
- Northwestern University (US)
- Shirley Ryan AbilityLab (US)
Publication Details
- Journal
- Osteoarthritis and Cartilage Open
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1016/j.ocarto.2025.100619
- Citations
- 1
- Primary Topic
- Knee injuries and reconstruction techniques
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- Foundation for Physical Medicine and Rehabilitation
- National Institute on Aging
- National Center for Advancing Translational Sciences