HIF-PH inhibitors induce pseudohypoxia in T cells and suppress the growth of microsatellite stable colorectal cancer by enhancing antitumor immune responses
Pseudohypoxia induced by HIF-PH inhibitors activates antitumor immune responses, at least in part, through the induction of IL-2 secretion from CD4<sup>+</sup> T cells in the spleen and tumor microenvironment, thereby enhancing immune efficacy against MSS CRC.
Authors
- Hiroshi Tazawa (ORCID: https://orcid.org/0000-0003-4658-1050)
- Akihiro Matsukawa (ORCID: https://orcid.org/0000-0002-5081-6089)
- Kazuhiro Noma
- Masayoshi Fujisawa (ORCID: https://orcid.org/0000-0003-4794-4837)
- Toshiaki Ohara (ORCID: https://orcid.org/0000-0003-1557-1589)
- Teizo Yoshimura (ORCID: https://orcid.org/0000-0002-3853-2075)
- Miao Tian (ORCID: https://orcid.org/0009-0004-2832-7096)
- Yuze Wang (ORCID: https://orcid.org/0000-0003-0004-4153)
- Yuehua Chen (ORCID: https://orcid.org/0009-0006-1343-7449)
- Yusuke Hamada
Institutions
- Okayama University (JP)
- Okayama University Hospital (JP)
Publication Details
- Journal
- Cancer Immunology Immunotherapy
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1007/s00262-025-04067-3
- Citations
- 5
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 4.68
Funders
- China Scholarship Council
- Okayama University
- Japan Society for the Promotion of Science