Transition metal/photocatalyst-free skeletal editing of indene with iodonium difluorodiazo reagent to access 2-(difluoromethyl)naphthalene
In this study, we design and synthesize a reactive difluorodiazo hypervalent iodine<sup>(III)</sup> reagent that facilitates the ring expansion of indene under mild basic conditions at room temperature. This protocol offers a practical and efficient route to a diverse array of 2-difluoromethyl naphthalene derivatives in good yields.
Authors
- Fa‐Guang Zhang (ORCID: https://orcid.org/0000-0002-0251-0456)
- Jun-An Ma
- Wei‐Hsin Chen (ORCID: https://orcid.org/0000-0001-5009-3960)
- Zhong‐Yong Yuan (ORCID: https://orcid.org/0000-0002-3790-8181)
- Mengtao Sun (ORCID: https://orcid.org/0000-0002-8153-2679)
- Zhi‐Qi Zhang (ORCID: https://orcid.org/0000-0001-5909-0408)
Institutions
- Tianjin University (CN)
- Tianjin Synthetic Material Research Institute (China) (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc01777g
- Citations
- 5
- Primary Topic
- Synthesis and Catalytic Reactions
- Type
- article
- Field-Weighted Citation Impact
- 4.68
Funders
- National Natural Science Foundation of China
- Tianjin University