Importance of the 3′-phosphate group of acetyl-coenzyme A for efficient histone lysine acetyltransferase catalysis
Acetyl-coenzyme A is a universal coenzyme involved in diverse biochemical reactions, including histone acetylation catalysed by histone lysine acetyltransferases. Combined enzyme assays and molecular dynamics simulations demonstrate that the 3'-phosphate group of acetyl-coenzyme A is important, but not essential, for productive histone lysine acetyltransferase catalysis.
Authors
- Jasmin Mecinović (ORCID: https://orcid.org/0000-0002-5559-3822)
- Laust Moesgaard (ORCID: https://orcid.org/0000-0002-5509-9832)
- Nurgül Bilgin (ORCID: https://orcid.org/0000-0002-7097-7218)
- Giordano Proietti (ORCID: https://orcid.org/0000-0001-7392-4712)
- Jacob Kongsted (ORCID: https://orcid.org/0000-0002-7725-2164)
Institutions
- University of Southern Denmark (DK)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc01562f
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00