A single-cell transcriptomic atlas of all cell types in the brain of 5xFAD Alzheimer mice in response to dietary inulin supplementation
These results provide a comprehensive overview on the transcriptomic changes in individual cells of the entire mouse brain in response to high fiber intake and a resourceful foundation for future mechanistic studies on the influence of diet and gut microbiome on the brain during neurodegeneration.
Authors
- Wan Zhou (ORCID: https://orcid.org/0000-0003-1410-6714)
- Carlos F. Ibáñez (ORCID: https://orcid.org/0000-0003-4090-0794)
- Meng Xie (ORCID: https://orcid.org/0000-0002-6388-9789)
- Houyu Zhang (ORCID: https://orcid.org/0000-0002-8772-3396)
- Xuetong Li (ORCID: https://orcid.org/0000-0003-0029-2296)
- Xiaoyan Wang (ORCID: https://orcid.org/0000-0002-6891-5560)
Institutions
- Capital Medical University (CN)
- Peking University (CN)
- Chinese Institute for Brain Research (CN)
Publication Details
- Journal
- BMC Biology
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1186/s12915-025-02230-x
- Citations
- 1
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.84
Funders
- Cancerfonden
- Karolinska Institutet
- Vetenskapsrådet
- Peking University