Subchondral injection of human umbilical cord mesenchymal stem cells ameliorates knee osteoarthritis by inhibiting osteoblast apoptosis and TGF-beta activity
The efficacy of UCMSCs for treating OA rats via SC injection was equivalent to that of IA; and even superior to IA in terms of subchondral bone phenotype via regulating apoptosis and TGF-β/pSmad2 signaling in osteoblasts, suggesting SC injection of UCMSCs as a potential and promising cell therapy for OA treatment.
Authors
- Pinger Wang (ORCID: https://orcid.org/0000-0002-4124-0188)
- Hongting Jin
- Peijian Tong (ORCID: https://orcid.org/0000-0003-0948-8674)
- Congzi Wu (ORCID: https://orcid.org/0000-0003-0857-4829)
- Jiali Chen (ORCID: https://orcid.org/0009-0009-9876-6103)
- HuiHui Xu
- Jianbo Xu (ORCID: https://orcid.org/0000-0002-1470-7264)
- Wenhua Yuan (ORCID: https://orcid.org/0000-0002-4126-821X)
- Haipeng Huang
- Qinwen Ge (ORCID: https://orcid.org/0000-0001-6227-1066)
- Zhen Wu
Institutions
- Zhejiang Chinese Medical University (CN)
- Tongde Hospital of Zhejiang Province (CN)
- Hangzhou Red Cross Hospital (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1186/s13287-025-04366-7
- Citations
- 5
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 8.34
Funders
- National Natural Science Foundation of China
- Zhejiang Chinese Medical University
- Natural Science Foundation of Zhejiang Province