Functional analysis of JPH2-knockout cardiomyocytes identifies ECCD as a novel indicator in a human cardiac modelJPH2
This study demonstrates JPH2's essential role in sustaining excitation-contraction coupling by stabilizing the junctional membrane complex, with its deficiency driving heart failure-like cardiac dysfunction. ECCD is established as a sensitive, comprehensive indicator for assessing JPH2-related impairment severity. These findings advance our understanding of JPH2 in cardiac pathology and position ECCD as a valuable tool for research and potential clinical evaluation, with JPH2 and calcium regulation emerging as promising therapeutic targets.
Authors
- Min Zhu
- Man Qi (ORCID: https://orcid.org/0009-0002-5818-8766)
- Wenjing Lu (ORCID: https://orcid.org/0000-0002-9479-3536)
- Feng Lan (ORCID: https://orcid.org/0000-0002-9038-4014)
- Yuting Yan
- Tianwei Guo (ORCID: https://orcid.org/0000-0002-2028-320X)
- Shuhong Ma (ORCID: https://orcid.org/0000-0002-9271-8030)
- Xujie Liu
- Fujian Wu (ORCID: https://orcid.org/0000-0003-0291-3236)
- Yongshuai Zhang (ORCID: https://orcid.org/0000-0001-8165-2446)
- Siyu Liu (ORCID: https://orcid.org/0000-0001-7089-2006)
- Hongyue Wang (ORCID: https://orcid.org/0000-0002-3070-0732)
- Meng Zhou (ORCID: https://orcid.org/0000-0001-5664-3871)
- Didaer Talanaite
Institutions
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- National Health and Family Planning Commission (CN)
- Chinese PLA General Hospital (CN)
- Beijing Anzhen Hospital (CN)
- Shanghai East Hospital (CN)
- Fu Wai Hospital (CN)
Publication Details
- Journal
- Stem Cell Research & Therapy
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1186/s13287-025-04323-4
- Citations
- 1
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Chinese Academy of Medical Sciences
- General Hospital of People’s Liberation Army
- Shenzhen Fundamental Research Program
- National Key Research and Development Program of China