Negative sampling strategies impact the prediction of scale-free biomolecular network interactions with machine learning

Our findings present a novel perspective for assessing the performance of ML models in inferring protein-molecular interactions with greater fairness. By addressing biases introduced by network properties, the DDB sampling approach provides a more balanced and precise assessment of model capabilities. These insights hold the potential to bolster the reliability of ML models in bioinformatics, fostering a more stringent evaluation framework for predicting protein-molecular interactions.