Two independent regulatory mechanisms synergistically contribute to P450-mediated insecticide resistance in a lepidopteran pest, Spodoptera exigua
Collectively, these results demonstrate that two distinct but synergistic mechanisms coordinately result in the overexpression of CYP321B1 involved in insecticide resistance in an agriculturally important insect pest, S. exigua. The information on mechanisms of metabolic resistance could help to understand the development of resistance to insecticides by other pests and contribute to designing effective integrated pest management strategies for the pest control.
Authors
- Xiangzhu Chen
- Jianya Su (ORCID: https://orcid.org/0000-0002-2508-2546)
- Anjiang Tan (ORCID: https://orcid.org/0000-0003-2431-6168)
- Cong Rao
- Bo Hu (ORCID: https://orcid.org/0000-0002-3749-3246)
- Zhiping Xing
- Kuitun Liu
- Yuting Zhang (ORCID: https://orcid.org/0009-0003-8386-2908)
Institutions
- Nanjing Agricultural University (CN)
- Linyi University (CN)
- Jiangsu University of Science and Technology (CN)
- Chinese Academy of Agricultural Sciences (CN)
- Sericultural Research Institute (CN)
- Ministry of Agriculture and Rural Affairs (CN)
Publication Details
- Journal
- BMC Biology
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1186/s12915-025-02228-5
- Citations
- 7
- Primary Topic
- Insect Resistance and Genetics
- Type
- article
- Field-Weighted Citation Impact
- 5.64
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Natural Science Foundation of Jiangsu Province