Optimism moderates the relationship between inflammatory polygenic risk and major depressive disorder in U.S. Military veterans
Findings suggest genetic risk for inflammation contributes to MDD vulnerability and that optimism may buffer this risk.
Authors
- Brenda Cabrera‐Mendoza (ORCID: https://orcid.org/0000-0003-4729-9997)
- Renato A Polimanti (ORCID: https://orcid.org/0000-0003-0745-6046)
- Joel Gelernter (ORCID: https://orcid.org/0000-0002-4067-1859)
- Cassie Overstreet (ORCID: https://orcid.org/0000-0003-2342-153X)
- Ian C. Fischer (ORCID: https://orcid.org/0000-0002-7343-071X)
- John Harrison Krystal (ORCID: https://orcid.org/0000-0001-6952-1726)
- Dan Qiu (ORCID: https://orcid.org/0000-0002-6049-2858)
- Robert H. Pietrzak (ORCID: https://orcid.org/0000-0002-5561-6414)
Institutions
- United States Department of Veterans Affairs (US)
- Yale University (US)
- VA Connecticut Healthcare System (US)
Publication Details
- Journal
- The World Journal of Biological Psychiatry
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1080/15622975.2025.2498352
- Citations
- 1
- Primary Topic
- Optimism, Hope, and Well-being
- Type
- article
- Field-Weighted Citation Impact
- 1.54