Cerebral Amyloid Angiopathy and Downstream Alzheimer Disease Plasma Biomarkers
In this cohort study of participants with no cognitive impairment, mild cognitive impairment, or dementia of the Alzheimer type, a novel association was found among CAA imaging markers, downstream AD plasma biomarkers, and cognitive declines in relation to brain Aβ burdens. The findings emphasize the importance of understanding the clinical effects of amyloid-related imaging abnormality-like CAA imaging markers in light of upcoming amyloid-targeted therapies.
Authors
- Jun Pyo Kim
- Sung Hoon Kang (ORCID: https://orcid.org/0000-0002-9156-3348)
- Fernando González‐Ortiz (ORCID: https://orcid.org/0000-0001-7897-9456)
- Eun Hye Lee (ORCID: https://orcid.org/0000-0001-8090-6571)
- Hyemin Jang (ORCID: https://orcid.org/0000-0003-3152-1274)
- Jihwan Yun (ORCID: https://orcid.org/0000-0002-2436-4947)
- Hee Jin Kim (ORCID: https://orcid.org/0000-0003-1554-2657)
- Young Ju Kim (ORCID: https://orcid.org/0000-0003-2927-6724)
- Sang Won Seo (ORCID: https://orcid.org/0000-0003-2568-0797)
- Daeun Shin (ORCID: https://orcid.org/0000-0003-4834-1026)
- Nicholas J. Ashton
- Duk L. Na (ORCID: https://orcid.org/0000-0003-1572-7862)
- Henrik Zetterberg
- Kaj Blennow
Institutions
- University of Science and Technology of China (CN)
- King's College London (GB)
- South London and Maudsley NHS Foundation Trust (GB)
- Samsung (South Korea) (KR)
- Soonchunhyang University (KR)
- Korea University Medical Center (KR)
- Stavanger University Hospital (NO)
- Sahlgrenska University Hospital (SE)
- Samsung Medical Center (KR)
- Seoul National University Hospital (KR)
- Centre for Mental Health (GB)
- Sorbonne Université (FR)
- Pitié-Salpêtrière Hospital (FR)
- UK Dementia Research Institute (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- Institut du Cerveau (FR)
- Indiana University School of Medicine
- University College London (GB)
- Indiana University – Purdue University Indianapolis (US)
- Sungkyunkwan University (KR)
- University of Gothenburg (SE)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.8842
- Citations
- 9
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 12.50
Funders
- Alzheimer's Association
- Demensförbundet
- EU Joint Programme – Neurodegenerative Disease Research
- Korea University Guro Hospital
- European Commission
- National Research Foundation
- Korea University
- National Research Foundation of Korea
- Hjärnfonden
- Vetenskapsrådet
- Iran Telecommunication Research Center
- Ministry of Science and ICT, South Korea
- Fondation pour la Recherche sur Alzheimer
- Samsung
- Korea National Institute of Health