Differential Effects of Rutin and Its Aglycone Quercetin on Cytotoxicity and Chemosensitization of HCT 116 Colon Cancer Cells to Anticancer Drugs 5-Fluorouracil and Doxorubicin
The results of the current study suggest that rutin and quercetin, although structural analogs, act as specific modulators of signaling pathways in cancer cells, differentially affecting cancer cell cytotoxicity and chemosensitization to anticancer drugs, based on the presence of a free hydroxyl group at the C-3 position of the flavonoid backbone at quercetin or rutinose in rutin.
Authors
- Iva Suman
- Robert Domitrović (ORCID: https://orcid.org/0000-0002-1235-504X)
- Alberta Jezidžić
- Dorotea Dobrić
Institutions
- University of Rijeka (HR)
Publication Details
- Journal
- Biology
- Published
- 2025-05-09
- DOI
- https://doi.org/10.3390/biology14050527
- Citations
- 5
- Primary Topic
- Plant Gene Expression Analysis
- Type
- article
- Field-Weighted Citation Impact
- 4.03