68Ga-NK224 PET/CT for Noninvasive Evaluation of PD-L1 Expression and Intertumor Heterogeneity: A Translational Exploratory Study
68Ga-NK224 provides a straightforward radiolabeling approach with high tumor-to-background contrast, enabling an accurate assessment of PD-L1 expression and visualization of heterogeneity across intrapatient lesions. Its ability to dynamically monitor PD-L1 occupancy in tumors offers a novel method for optimizing immunotherapy dosing regimens.
Authors
- Liang Zhao (ORCID: https://orcid.org/0000-0002-1303-8775)
- Jianhao Chen (ORCID: https://orcid.org/0000-0003-1599-2420)
- Long Sun (ORCID: https://orcid.org/0000-0002-3869-4832)
- Wei Guo (ORCID: https://orcid.org/0000-0002-7868-2684)
- Haojun Chen (ORCID: https://orcid.org/0000-0002-9101-8884)
- Lingyu Yu (ORCID: https://orcid.org/0009-0000-6959-268X)
- Yaqing Dai (ORCID: https://orcid.org/0009-0001-3378-4644)
- Jianyang Fang (ORCID: https://orcid.org/0009-0008-1722-6088)
- Hao Fu (ORCID: https://orcid.org/0000-0003-0121-0248)
- Hua Wu (ORCID: https://orcid.org/0000-0001-6072-9176)
- Yizhen Pang (ORCID: https://orcid.org/0000-0001-7710-5925)
- Qin Lin (ORCID: https://orcid.org/0000-0002-4391-8706)
- Shan Zhong (ORCID: https://orcid.org/0000-0002-9507-7806)
- Yi Ding (ORCID: https://orcid.org/0009-0009-0999-499X)
- Hui Zhou (ORCID: https://orcid.org/0000-0002-3256-317X)
- Dan Ruan (ORCID: https://orcid.org/0000-0003-3400-7684)
Institutions
- National University of Singapore (SG)
- Xiamen University (CN)
- First Affiliated Hospital of Xiamen University (CN)
- Xiamen Institute of Rare-earth Materials (CN)
- Clinical Nutrition Research Centre (SG)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-0160
- Citations
- 6
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 6.27
Funders
- National Natural Science Foundation of China
- Science Fund for Distinguished Young Scholars of Fujian Province