Formulation and Evaluation of Giloy Berberine-Loaded Hydrocolloidal Patches for Acne Treatment

Abstract: Giloy, scientifically known as Tinospora Cordifolia, is a widely recognized medicinal plant in Ayurveda. It is a deciduous climbing shrub with heart-shaped leaves belonging to Menispermaceae family, acting as one of the main sources of new pharmaceuticals and health care products. The plant is genetically diverse, containing different active components, including steroids, aliphatics, alkaloids, glycosides, and diterpenoid lactones. This herb possesses anti- inflammatory, antibacterial, immunomodulating agent, anti-viral, anti-diabetic properties in addition to being a strong antioxidant.1 A primary method for determining the antimicrobial activity of a compound and its active substance was carried out on invitro model through agar well diffusion method on Propionobacterium Acne. Observations of antibacterial activity were carried out by reviewing clear zones indicating the inhibition zones.2 Studies revealed that T. cordifolia is an excellent drug and does not have any adverse or toxic effects till now. There is a new invention for topical acne treatment called acne patch. The purpose of this study was to formulate an acne patch preparation from Giloy Stem extract with a combination of Xanthan gum and Propylene glycol and other excipients against Propionibacterium acnes bacteria. Acne patch preparation was evaluated for physical characteristics, and tested for its antibacterial effectiveness activity