Inadequate imipenem dosing in patients with decreased kidney function: a global clinical pharmacokinetic study
The highest on-label imipenem dosing regimens failed to attain 100% ƒT > MIC<sub>4mg/L</sub> in patients with decreased kidney function. Higher dosing may be necessary to cover MIC of 4 mg/L. Future trials should explore their efficacy, toxicity, and the utility of model-informed precision dosing in this population.
Authors
- Letao Li (ORCID: https://orcid.org/0000-0002-4692-9689)
- Birgit C. P. Koch (ORCID: https://orcid.org/0000-0002-1202-3643)
- Dao Xuan Co (ORCID: https://orcid.org/0000-0002-3182-2993)
- Tim Preijers (ORCID: https://orcid.org/0000-0001-6953-0358)
- Tim J L Smeets (ORCID: https://orcid.org/0000-0002-2197-3405)
- Jan Strojil (ORCID: https://orcid.org/0000-0003-3170-5831)
- Angela Csaki Huttner (ORCID: https://orcid.org/0000-0002-8380-368X)
- Truong Anh Quan (ORCID: https://orcid.org/0000-0002-8462-3410)
- Sebastiaan D. T. Sassen (ORCID: https://orcid.org/0000-0002-4525-638X)
- Jean E. Terrier (ORCID: https://orcid.org/0000-0002-5878-4878)
Institutions
- Charles University (CZ)
- University Hospital of Geneva (CH)
- Bạch Mai Hospital (VN)
- Palacký University Olomouc (CZ)
Publication Details
- Journal
- Clinical Microbiology and Infection
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1016/j.cmi.2025.05.005
- Citations
- 1
- Primary Topic
- Antibiotics Pharmacokinetics and Efficacy
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Hôpitaux Universitaires de Genève