Pseudomonas aeruginosa in wound infections: Genomic characterization and emergence of hypervirulent ST1965/ST3418 strains co-harbouring exoU and exoS
P. aeruginosa isolates from wound infections displayed sporadic genomic profiles, high antibiotic susceptibility, and robust biofilm formation. The emergence of exoU+/exoS+ hypervirulent clones (ST1965 and ST3418), characterized by enhanced virulence and biofilm production, highlights their potential to cause treatment-refractory infections and severe clinical outcomes. Continuous surveillance and tailored therapeutic approaches are imperative for managing infections caused by these clones.
Authors
- Wenying Xia (ORCID: https://orcid.org/0000-0003-2359-1379)
- Hong Xin (ORCID: https://orcid.org/0000-0002-9709-9267)
- Litao Zhang (ORCID: https://orcid.org/0000-0003-4918-611X)
- Genyan Liu (ORCID: https://orcid.org/0000-0002-1004-2517)
- Yulin Hu (ORCID: https://orcid.org/0000-0001-5677-8987)
- Zexuan Li (ORCID: https://orcid.org/0009-0004-7067-6572)
- Zhongming Tan (ORCID: https://orcid.org/0000-0003-2731-7668)
Institutions
- Jiangsu Provincial Center for Disease Control and Prevention (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Journal of Global Antimicrobial Resistance
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1016/j.jgar.2025.05.007
- Citations
- 2
- Primary Topic
- Bacterial biofilms and quorum sensing
- Type
- article
- Field-Weighted Citation Impact
- 1.61