Resistance to tuberculin skin test/interferon-gamma release assay conversion among highly TB exposed, HIV infected goldminers in South Africa
Similar to previous longitudinal cohort studies, we found a small proportion of HIV-infected goldminers who resisted TST/IGRA conversion. This was positively associated with prior IPT, but negatively associated with lower CD4 count and being from Mozambique. However, mechanisms underlying TST/IGRA conversion resistance are not well understood.
Authors
- Thobani Ntshiqa (ORCID: https://orcid.org/0000-0002-0752-3192)
- Kavindhran Velen (ORCID: https://orcid.org/0000-0001-8577-3915)
- Sibuse Ginindza
- Robert S. Wallis (ORCID: https://orcid.org/0000-0001-6152-5183)
- Lindiwe Nhlangulela
- Violet Chihota (ORCID: https://orcid.org/0000-0003-1444-9266)
- Gavin Churchyard (ORCID: https://orcid.org/0000-0002-4269-3699)
- W. Henry Boom (ORCID: https://orcid.org/0000-0001-5760-9595)
- Salome Charalambous (ORCID: https://orcid.org/0000-0001-7143-1009)
- Thomas R. Hawn (ORCID: https://orcid.org/0000-0003-2368-3185)
Institutions
- University of the Witwatersrand (ZA)
- Vanderbilt University (US)
- University of Washington (US)
- Aurum Institute (ZA)
- Seattle University (US)
- Case Western Reserve University (US)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1371/journal.pone.0318819
- Citations
- 1
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.40
Funders
- National Institutes of Health