Waning of anti-SARS-CoV-2 antibodies after the first wave of the COVID-19 pandemic in 2020: A 12-month-evaluation in three population-based European studies
From population-based cohorts, anti-S IgG levels remained stable during the first 4 months following SARS-CoV-2 infection. Most of the decay occurred afterward; nearly one-third of people seroreverted 6 and 12 months later. Low IgG levels and seroneutralization negativity were independent predictors of seroreversion.
Authors
- Armin Rauschenberger (ORCID: https://orcid.org/0000-0001-6498-4801)
- Sophie Novelli (ORCID: https://orcid.org/0000-0003-0154-9786)
- Jérôme Le Chenadec
- Carmelite Manto
- Marc Paul O’Sullivan (ORCID: https://orcid.org/0000-0002-6184-3306)
- Michel Vaillant (ORCID: https://orcid.org/0000-0003-4714-8128)
- Alexey Kolodkin (ORCID: https://orcid.org/0000-0002-7466-5027)
- Michael Höelscher (ORCID: https://orcid.org/0000-0002-7642-1835)
- Christina Reinkemeyer
- Inge Kroidl (ORCID: https://orcid.org/0000-0002-6949-346X)
- Rejko Krueger (ORCID: https://orcid.org/0000-0003-4258-6241)
- Noemi Castelletti (ORCID: https://orcid.org/0000-0002-6598-5352)
- Josiane Warszawski (ORCID: https://orcid.org/0000-0001-8590-7952)
- Stéphane Priet (ORCID: https://orcid.org/0000-0001-7102-3654)
- Laurence Meyer (ORCID: https://orcid.org/0000-0001-5707-2062)
- Venkata Satagopam (ORCID: https://orcid.org/0000-0002-6532-5880)
- Chantal J. Snoeck (ORCID: https://orcid.org/0000-0002-0000-1850)
- Soumyabrata Ghosh (ORCID: https://orcid.org/0000-0003-0659-6733)
- Karine Barthélémy (ORCID: https://orcid.org/0000-0001-6343-2175)
- Dmitry Bulaev (ORCID: https://orcid.org/0000-0002-0650-8871)
- Xavier de Lamballerie
- Andreas Wieser (ORCID: https://orcid.org/0000-0003-1090-8277)
Institutions
- Inserm (FR)
- Centre Hospitalier de Luxembourg (LU)
- University of Luxembourg (LU)
- Université de Versailles Saint-Quentin-en-Yvelines (FR)
- Aix-Marseille Université (FR)
- Université Paris-Saclay (FR)
- Helmholtz Zentrum München (DE)
- Assistance Publique – Hôpitaux de Paris (FR)
- Luxembourg Institute of Health (LU)
- Centre de recherche en Epidémiologie et Santé des Populations (FR)
- Fraunhofer Institute for Translational Medicine and Pharmacology (DE)
- German Center for Infection Research (DE)
- Bicêtre Hospital (FR)
- Ludwig-Maximilians-Universität München (DE)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1371/journal.pone.0320196
- Citations
- 5
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 6.98
Funders
- Accenture
- André Losch Fondation
- Institut National de la Santé et de la Recherche Médicale
- Universität Bielefeld
- Ludwig-Maximilians-Universität München
- Rheinische Friedrich-Wilhelms-Universität Bonn
- Roche Diagnostics