Advancing Personalized Medicine Using Genomic Data Analysis and Predictive Modeling
Personalized medicine is changing because it allows for more personalized treatment plans thanks to the combination of genetic data analysis and prediction models. This study uses large genetic datasets to create and test predictive models that find how each person will respond to treatment. Along with more standard statistical methods like regression analysis, we used a number of different computer techniques, such as machine learning tools like Random Forests, Support Vector Machines, and Neural Networks. As part of our method, we preprocessed genetic data, chose features to find important variables, and trained the model using a split-sample validation method to make sure it was reliable. The models were judged on how well they could predict treatment results based on their accuracy, sensitivity, and specificity. Key results show that ensemble methods, especially Random Forests, work better than single methods because they can handle the complex and high-dimensional nature of genetic data better. Our best model was able to guess 89% of the time, which shows that it has a lot of promise to make professional decision-making better. This model worked very well with a variety of genetic datasets, which made it even more useful for a wide range of patient groups. Our study shows how useful it is to use advanced machine learning methods along with genetic data to make personalized medicine better. Precision medicine promises to change the way healthcare is provided by making diagnoses more accurate, treatment plans more effective, and results better. More study and use of these models could lead to wide use in hospital settings, which would improve care for patients around the world.
Authors
- Pradnya Sulas Borkar (ORCID: https://orcid.org/0000-0002-1574-3435)
- Parikshit N. Mahalle (ORCID: https://orcid.org/0000-0001-5474-6826)
- Saurabh Bhattacharya (ORCID: https://orcid.org/0000-0002-4202-8437)
- Jothi Prakash B S
- Wood Andrew R.
Institutions
- Galgotias University (IN)
- Symbiosis International University (IN)
Publication Details
- Published
- 2025-03-05
- DOI
- https://doi.org/10.1109/esci63694.2025.10988289
- Primary Topic
- Genetics, Bioinformatics, and Biomedical Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00