Keratin 6A promotes skin inflammation through JAK1-STAT3 activation in keratinocytes
Our findings indicate that KRT6A expression increases following epidermal barrier disruption and contributes to exacerbated skin inflammation in disease conditions. Targeting KRT6A may represent a novel therapeutic approach for inflammatory skin diseases associated with epidermal dysfunction.
Authors
- M Wang (ORCID: https://orcid.org/0009-0003-2772-9117)
- Zixin Tan (ORCID: https://orcid.org/0009-0008-4062-6573)
- Ji Li (ORCID: https://orcid.org/0000-0003-0931-5562)
- Ben Wang (ORCID: https://orcid.org/0000-0003-2916-3447)
- Yaling Wang (ORCID: https://orcid.org/0000-0002-9829-1744)
- Yisheng Cai
- Zhili Deng (ORCID: https://orcid.org/0000-0002-8590-9840)
- X. Y. Xiao
- San Xu (ORCID: https://orcid.org/0000-0002-4958-935X)
- Mengting Chen (ORCID: https://orcid.org/0000-0001-9379-6818)
Institutions
- Central South University (CN)
- Hunan Normal University (CN)
- National Clinical Research (US)
- Hunan Provincial People's Hospital (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- Journal of Biomedical Science
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1186/s12929-025-01143-9
- Citations
- 8
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 16.04
Funders
- National Natural Science Foundation of China
- Central South University
- Young Scientists Fund
- Xiangya Hospital, Central South University
- Key Technologies Research and Development Program
- National Key Research and Development Program of China
- National Science Fund for Distinguished Young Scholars