Corymbinols A and B: Bis-β-triketone Conjugates of Sesquiterpene and Chalcone from the Fruit of <i>Corymbia citriodora</i>
Corymbinols A (<b>1</b>) and B (<b>2a</b>/<b>2b</b>), unprecedented bis-β-triketone-sesquiterpene and -chalcone hybrids, together with their biogenic precursors corymbinol C (<b>3</b>) and rhodomyrtosone E (<b>4</b>) were isolated from the untapped fruit of <i>Corymbia citriodora</i>. The absolute configurations of these compounds were determined by NMR spectroscopy, electronic circular dichroism (ECD) calculations, and X-ray crystallography. Compound <b>1</b> exhibited moderate inhibitory activity against cuproptosis in HepG2 cells by 31% at a nontoxic concentration of 20 μM.
Authors
- Xiao Ding (ORCID: https://orcid.org/0000-0002-3287-7611)
- Yu‐Cheng Gu (ORCID: https://orcid.org/0000-0002-6400-6167)
- Xiao‐Jiang Hao (ORCID: https://orcid.org/0000-0001-9496-2152)
- Liyun Zhao (ORCID: https://orcid.org/0000-0001-8423-7766)
- Sheng‐Xiang Qiu (ORCID: https://orcid.org/0000-0001-8832-041X)
- Aikebaier Jumai (ORCID: https://orcid.org/0000-0001-6971-4042)
- Xuan Ma (ORCID: https://orcid.org/0000-0003-4598-9505)
- X. F. Duan (ORCID: https://orcid.org/0000-0002-5388-2612)
- Yulin Li (ORCID: https://orcid.org/0009-0003-2053-1458)
Institutions
- Kunming Institute of Botany (CN)
- Chinese Academy of Sciences (CN)
- Institute of Oceanology (CN)
- South China Sea Institute Of Oceanology (CN)
- South China Botanical Garden (CN)
- Syngenta (China) (CN)
- China National Botanical Garden
Publication Details
- Journal
- Organic Letters
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1021/acs.orglett.5c01245
- Citations
- 2
- Primary Topic
- Natural Compound Pharmacology Studies
- Type
- article
- Field-Weighted Citation Impact
- 3.50
Funders
- National Natural Science Foundation of China
- Chinese Academy of Sciences