Complement 3 (C3) within the hypothalamic arcuate nucleus is a potential key mediator of the effect of enhanced nutrition on reproductive development in young bull calves
This study highlights an effect of altered plane of nutrition in early life on the molecular control of the hypothalamic ARC. Additionally, results generated suggest a potential role for the C3 gene in mediating the interaction between enhanced metabolic status with reproductive development within the ARC, regulated by miR-2419-3p.
Authors
- Kate Keogh (ORCID: https://orcid.org/0000-0001-8338-5177)
- Seán Fair (ORCID: https://orcid.org/0000-0003-0085-1537)
- David A. Kenny (ORCID: https://orcid.org/0000-0002-5553-7548)
- P. Lonergan (ORCID: https://orcid.org/0000-0001-5598-5044)
- Stephen P Coen
Institutions
- University College Dublin (IE)
- Teagasc - The Irish Agriculture and Food Development Authority (IE)
- University of Limerick (IE)
Publication Details
- Journal
- BMC Genomics
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1186/s12864-025-11656-0
- Citations
- 1
- Primary Topic
- Growth Hormone and Insulin-like Growth Factors
- Type
- article
- Field-Weighted Citation Impact
- 1.29
Funders
- Science Foundation Ireland