Prmt1-mediated methylation regulates Ncoa4 stability to transactivate Adamts genes and promote bone extracellular matrix degradation in chronic hematogenous osteomyelitis
These findings identify Prmt1 as a pivotal regulator of bone ECM degradation in osteomyelitis through stabilization of Ncoa4 and highlight Prmt1 as a promising therapeutic target for osteomyelitis treatment.
Authors
- Wentao Zhang (ORCID: https://orcid.org/0000-0002-9075-541X)
- Xun Chen (ORCID: https://orcid.org/0000-0003-1374-6154)
- Fei Cong
- Ning Duan (ORCID: https://orcid.org/0000-0003-3974-4683)
- Tao Song (ORCID: https://orcid.org/0000-0001-7929-2074)
Institutions
- Xi'an Honghui Hospital (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Biology Direct
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1186/s13062-025-00652-9
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Honghui Hospital