Mediation of the Association Between <i>APOE</i> ε4 Genotype, Cognition, and Dementia by Neuropathology Imaging Markers in the Rotterdam Study
In this population-based cohort study, we found that an estimated one-fourth of the effect of <i>APOE</i> ε4 on cognition is mediated by structural brain imaging markers, driven mainly by cerebral microbleeds. For dementia, mediation by these markers was limited.
Authors
- Jeremy A. Labrecque (ORCID: https://orcid.org/0000-0002-1028-2158)
- Meike Willemijn Vernooij (ORCID: https://orcid.org/0000-0003-4658-2176)
- M. Arfan Ikram (ORCID: https://orcid.org/0000-0003-0372-8585)
- Frank J. Wolters (ORCID: https://orcid.org/0000-0003-2226-4050)
- Jacqueline J. Claus (ORCID: https://orcid.org/0000-0001-7047-7064)
- Mathijs T. Rosbergen
Institutions
- Erasmus MC (NL)
Publication Details
- Journal
- Neurology
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1212/wnl.0000000000213679
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00