Plasma concentrations of neurofilament light, p-Tau231 and glial fibrillary acidic protein are elevated in patients with chronic kidney disease and correlate with measured glomerular filtration rate
Patients with CKD had elevated plasma concentrations of NfL, p-Tau231 and GFAP compared with controls, and these biomarkers were inversely correlated with mGFR. Measured GFR was a significant, independent predictor of plasma concentrations of NfL and GFAP in patients with CKD. The mechanisms underlying this association need further investigation. Plasma levels of NfL and GFAP should be interpreted cautiously in patients with marked reductions in GFR.
Authors
- Nicholas James Ashton (ORCID: https://orcid.org/0000-0002-3579-8804)
- T. Gama Axelsson
- Markus Axelsson (ORCID: https://orcid.org/0000-0003-2036-4007)
- Maria K Eriksson Svensson (ORCID: https://orcid.org/0000-0001-7545-5585)
- Gregor Guron
- Burak Arslan (ORCID: https://orcid.org/0000-0001-6629-5153)
- Henrik Zetterberg
- Aso Saeed
- Kaj Blennow
Institutions
- Uppsala University (SE)
- University of Science and Technology of China (CN)
- University of Wisconsin–Madison (US)
- Sahlgrenska University Hospital (SE)
- Sorbonne Université (FR)
- Pitié-Salpêtrière Hospital (FR)
- UK Dementia Research Institute (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- Institut du Cerveau (FR)
- University College London (GB)
- University of Gothenburg (SE)
Publication Details
- Journal
- BMC Nephrology
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1186/s12882-025-04130-2
- Citations
- 9
- Primary Topic
- Chronic Kidney Disease and Diabetes
- Type
- article
- Field-Weighted Citation Impact
- 12.88
Funders
- Göteborgs Universitet