GPD1L supports glycerol-3-phosphate and triacylglycerol synthesis and promotes tumor progression in HCC
GPD1L is overexpressed in human HCCs and is associated with worse clinical outcomes. Aberrant GPD1L expression, driven by ELF1, facilitates conversion of DHAP to G3P to support triacylglycerol synthesis in HCC, promoting tumor growth and metastasis.
Authors
- Luqing Zhao (ORCID: https://orcid.org/0000-0003-1986-3511)
- Daniel Wai‐Hung Ho (ORCID: https://orcid.org/0000-0003-3884-296X)
- Lü Tian (ORCID: https://orcid.org/0000-0002-5893-0169)
- Joyce Man‐Fong Lee
- Charles Shing Kam (ORCID: https://orcid.org/0000-0002-7490-0111)
- Irene Oi‐Lin Ng (ORCID: https://orcid.org/0000-0001-7532-2029)
- Lo‐Kong Chan (ORCID: https://orcid.org/0000-0003-3082-1013)
- Karen Man‐Fong Sze (ORCID: https://orcid.org/0000-0002-7997-5331)
- Eva Lee
- Xin Zhang (ORCID: https://orcid.org/0000-0002-8582-1128)
- Tiffany Ching-Yun Yu (ORCID: https://orcid.org/0009-0007-9953-0173)
- Yu-Man Tsui
Institutions
- Queen Mary Hospital (CN)
- State Key Laboratory of Synthetic Chemistry (CN)
- University of Hong Kong (HK)
Publication Details
- Journal
- Hepatology
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1097/hep.0000000000001394
- Citations
- 3
- Primary Topic
- Lipid metabolism and biosynthesis
- Type
- article
- Field-Weighted Citation Impact
- 3.34