Spinal Instability Neoplastic Score as a Predictor of Vertebral Fracture in Patients Undergoing Radiation Therapy for Spinal Metastases: A Single-Institution Study
These findings support that SINS is a useful tool for estimating VCF risk, with lesion location, metastasis bone morphology, and presence of <50% collapse being the strongest predictors. Additionally, findings suggest that bone-strengthening medications such as bisphosphonates may mitigate the risk of developing VCF after RT.
Authors
- Shyam Kumar Tanguturi (ORCID: https://orcid.org/0000-0001-6479-1946)
- Thomas Johnson (ORCID: https://orcid.org/0000-0003-1045-456X)
- Kee‐Young Shin (ORCID: https://orcid.org/0000-0002-3451-8516)
- Todd A. Perkins
- Tracy Anne Balboni (ORCID: https://orcid.org/0000-0001-6564-6951)
- David B. Hackney (ORCID: https://orcid.org/0000-0001-9014-1998)
- Michael W. Groff (ORCID: https://orcid.org/0000-0003-1873-9578)
- Alexander Spektor (ORCID: https://orcid.org/0000-0002-1085-3205)
- Wenxin Xu (ORCID: https://orcid.org/0000-0002-8450-2037)
- Neil V. Klinger (ORCID: https://orcid.org/0000-0003-1219-1601)
- David Kozono (ORCID: https://orcid.org/0000-0002-8916-396X)
- Ron N. Alkalay (ORCID: https://orcid.org/0000-0002-9198-8039)
- Mai Anh Huynh (ORCID: https://orcid.org/0000-0003-0641-9745)
- Ellen Kim (ORCID: https://orcid.org/0000-0001-9379-0192)
- Heejoo Kang (ORCID: https://orcid.org/0000-0001-7543-1284)
- Maeve Dillon-Martin
- Cara Richards
- Patrick J. Doyle (ORCID: https://orcid.org/0009-0004-5001-933X)
- Sarah Caplan (ORCID: https://orcid.org/0000-0001-8037-8836)
- Claire Novack
Institutions
- Brigham and Women's Hospital (US)
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- Dana-Farber Cancer Institute (US)
Publication Details
- Journal
- Advances in Radiation Oncology
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1016/j.adro.2025.101803
- Primary Topic
- Management of metastatic bone disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- Beth Israel Deaconess Medical Center
- Exelixis
- Eisai
- National Institutes of Health
- Genentech
- National Cancer Institute