SBRT for bridging and downstaging HCC before transplant
SBRT is an emerging therapy for patients with HCC awaiting LT, with limited data available on its safety and efficacy. Our study provides crucial insights for physicians and researchers, demonstrating that SBRT is a safe and effective option for bridging patients with HCC to transplantation. These findings are important for optimizing treatment strategies and providing patients with additional therapeutic options while awaiting transplantation. However, the lower response rates and higher recurrence in the downstaging group highlight the need for further research to improve patient selection and tailor treatments for optimal outcomes.
Authors
- Rebecca Wong (ORCID: https://orcid.org/0000-0001-7210-3330)
- Christian Tibor Josef Magyar
- Grainne M. O’Kane (ORCID: https://orcid.org/0000-0002-8690-403X)
- Elmar Jaeckel (ORCID: https://orcid.org/0000-0003-4108-7192)
- Blayne Amir Sayed (ORCID: https://orcid.org/0000-0003-3224-8871)
- Aruz Mesci (ORCID: https://orcid.org/0000-0002-8327-794X)
- Zhihao Li (ORCID: https://orcid.org/0000-0002-5654-7043)
- Nazia Selzner (ORCID: https://orcid.org/0000-0002-9435-2597)
- I. McGilvray
- Marco P. A. W. Claasen (ORCID: https://orcid.org/0000-0001-8218-3119)
- Luckshi Rajendran (ORCID: https://orcid.org/0000-0002-2716-7121)
- Michael Yan (ORCID: https://orcid.org/0000-0002-8387-6563)
- Saheli Saha (ORCID: https://orcid.org/0000-0001-5555-3102)
- Aisling Barry (ORCID: https://orcid.org/0000-0003-2734-7090)
- Markus Selzner (ORCID: https://orcid.org/0000-0002-4326-0887)
- Mark S. Cattral (ORCID: https://orcid.org/0000-0001-8416-9660)
- Robert C. Grant (ORCID: https://orcid.org/0000-0002-9821-0377)
- Chaya Ganor Shwaartz (ORCID: https://orcid.org/0000-0003-2841-9834)
- Tae Kyoung Kim (ORCID: https://orcid.org/0000-0001-5193-1428)
- Jelena Danilović Luković (ORCID: https://orcid.org/0000-0003-2411-5032)
- Laura A. Dawson (ORCID: https://orcid.org/0000-0003-2768-3350)
- Cameron Lee (ORCID: https://orcid.org/0009-0004-4638-3059)
- John Kim
- Anand Ghanekar (ORCID: https://orcid.org/0000-0003-2966-4145)
- Trevor Reichman
- Gonzalo Sapisochin
- C. Naidoo
- Ali Hosni
- Arndt Vogel
Institutions
- University of Bern (CH)
- University Health Network (CA)
- University of Toronto (CA)
- University College Cork (IE)
- University Hospital of Bern (CH)
- Erasmus MC (NL)
- Cork University Hospital (IE)
- Princess Margaret Cancer Centre (CA)
- Medizinische Hochschule Hannover (DE)
- St. Vincent's University Hospital (IE)
- Erasmus MC Transplant Institute
Publication Details
- Journal
- JHEP Reports
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1016/j.jhepr.2025.101451
- Citations
- 2
- Primary Topic
- Hepatocellular Carcinoma Treatment and Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 2.64