Hyperoside modulates bile acid and fatty acid metabolism, presenting a potentially promising treatment for non-alcoholic fatty liver disease
Our findings suggest that hyperoside alleviates NAFLD by modulating fatty acid and bile acid metabolism through FXR and ACLY, suggesting its potential as a multi-effect candidate drug for the treatment of NAFLD.
Authors
- Yang Wang (ORCID: https://orcid.org/0000-0001-9697-5352)
- Qiang Jia (ORCID: https://orcid.org/0000-0001-6689-5255)
- Haiyang Wang (ORCID: https://orcid.org/0000-0001-5612-908X)
- Shenshen Yang (ORCID: https://orcid.org/0000-0003-2872-7263)
- Xue Rong
- Liwen Han (ORCID: https://orcid.org/0000-0002-2227-1632)
- Ying Yang (ORCID: https://orcid.org/0000-0001-8305-1978)
- Xiaoli Liu (ORCID: https://orcid.org/0000-0003-2904-4413)
- Yihan Ma
- Yubo Li (ORCID: https://orcid.org/0000-0003-0455-0969)
- Fusheng Liu (ORCID: https://orcid.org/0000-0003-1175-5209)
- Songsong Wang (ORCID: https://orcid.org/0000-0001-7843-7630)
Institutions
- Tianjin University of Traditional Chinese Medicine (CN)
- Shandong University of Traditional Chinese Medicine (CN)
- Qingdao University of Science and Technology (CN)
- Changchun University of Chinese Medicine (CN)
- Shandong Academy of Pharmaceutical Sciences (CN)
- Shandong First Medical University (CN)
- Shandong Academy of Chinese Medicine (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1016/j.jare.2025.05.014
- Citations
- 8
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 10.83