Nickel-Catalyzed Enantioselective Hydroboration of Styrenes

Abstract Herein, we established a Ni-catalyzed enantioselective hydroboration process of styrene derivatives using a chiral Box ligand with B2pin2 as the hydroboration reagent. This approach demonstrates the feasibility of stereoselective transmetalation of a benzylic carbon–nickel bond using B2pin2. The sought-after stable borated product can be achieved with elevated regio- and enantioselectivity under mild circumstances.