PTPN22 as a therapeutic target in intervertebral disc degeneration: Modulating mitophagy and pyroptosis through the PI3K/AKT/mTOR axis
In summary, PTPN22 knockdown alleviates IDD progression by reducing pyroptosis and ECM degradation through enhanced mitophagy. This highlights PTPN22 as a critical contributor to IDD and a promising therapeutic target.
Authors
- Haibo Liang (ORCID: https://orcid.org/0009-0000-6316-7885)
- Haiming Jin (ORCID: https://orcid.org/0000-0003-2666-8415)
- Sunlong Li
- Zhenya Chen (ORCID: https://orcid.org/0000-0002-5900-8547)
- Yang Shu (ORCID: https://orcid.org/0000-0002-1596-5943)
- Xiangyang Wang (ORCID: https://orcid.org/0000-0003-3435-2277)
- Zhouwei Wu (ORCID: https://orcid.org/0000-0003-4370-5900)
- Qihang Wu (ORCID: https://orcid.org/0000-0001-9449-4723)
- Yuxuan Zhu (ORCID: https://orcid.org/0000-0003-3624-9564)
- Yeheng Huang
- Yifeng Shi
Institutions
- Wenzhou Medical University (CN)
- Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University (CN)
Publication Details
- Journal
- Journal of Advanced Research
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1016/j.jare.2025.05.017
- Citations
- 8
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 11.77