Regulatory Mechanism of CRTC1 on Autophagy and GluA2 Expression in Epilepsy
CRTC1 indirectly influences the expression of synaptic-related proteins and GluA2 by directly modulating autophagy during the pathological process of epilepsy. The findings of this study reveal novel molecular targets for the treatment of epilepsy.
Authors
- Liqian Zhou (ORCID: https://orcid.org/0000-0002-1526-2551)
- Dan Li (ORCID: https://orcid.org/0000-0003-2635-4176)
- Yuqin Wang (ORCID: https://orcid.org/0000-0002-2144-0473)
- Lin Yang (ORCID: https://orcid.org/0009-0009-5135-8129)
- Shaoping Huang (ORCID: https://orcid.org/0009-0001-0897-8164)
- Yuying Wang (ORCID: https://orcid.org/0000-0002-0514-5327)
Institutions
- Shanxi Medical University (CN)
- Shaanxi Provincial People's Hospital (CN)
- Second Affiliated Hospital of Xi'an Jiaotong University (CN)
- Shanxi Provincial People’s Hospital (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Molecular Neurobiology
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1007/s12035-025-04971-w
- Primary Topic
- Autophagy in Disease and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00