Tie2 activity in cancer associated myofibroblasts serves as novel target against reprogramming of cancer cells to embryonic-like cell state and associated poor prognosis in oral carcinoma patients
CAF-specific Tie2 activity may serve as direct stromal-target against cancer cell plasticity leading to poor prognosis of oral cancer patients. Overall, our work has provided wider applicability of Tie2-specific functions in tumor biology, along with its known role in endothelial cell-specific function.
Authors
- Pattatheyil Arun (ORCID: https://orcid.org/0000-0002-7828-5777)
- Uday Saha
- Sillarine Kurkalang
- Ankit Kumar Patel (ORCID: https://orcid.org/0000-0003-0150-2769)
- Subhashree Jena (ORCID: https://orcid.org/0000-0002-3859-1403)
- Shantanu Saha Roy
- Nidhan K. Biswas (ORCID: https://orcid.org/0000-0001-7960-3290)
- Moulinath Acharya (ORCID: https://orcid.org/0000-0001-8013-7426)
- Rajeev Sharan (ORCID: https://orcid.org/0000-0002-3487-3884)
- Jayasri Das Sarma (ORCID: https://orcid.org/0000-0002-3980-4060)
- Joshua Stephen Kingsly (ORCID: https://orcid.org/0000-0002-6809-3747)
- Paromita Mitra
- Arnab Ghosh (ORCID: https://orcid.org/0000-0002-8157-5062)
- Sandeep Singh (ORCID: https://orcid.org/0000-0002-2589-4835)
- Mohit Kumar Jolly (ORCID: https://orcid.org/0000-0002-6631-2109)
- Harshavardhan BV (ORCID: https://orcid.org/0000-0001-7921-1246)
- Sumitava Roy
- Arindam Maitra (ORCID: https://orcid.org/0000-0002-0249-8856)
- Priyanka Prasad
- Santosh Kumar Mondal
Institutions
- Indian Institute of Science Education and Research Kolkata (IN)
- University of Chicago (US)
- Tata Medical Center (IN)
- Regional Centre for Biotechnology (IN)
- National Institute of Biomedical Genomics (IN)
- Indian Institute of Science Bangalore (IN)
- All India Institute of Medical Sciences (IN)
- Umeå University (SE)
Publication Details
- Journal
- Journal of Experimental & Clinical Cancer Research
- Published
- 2025-05-10
- DOI
- https://doi.org/10.1186/s13046-025-03405-8
- Citations
- 3
- Primary Topic
- Cancer Cells and Metastasis
- Type
- article
- Field-Weighted Citation Impact
- 3.14
Funders
- Department of Science and Technology, Ministry of Science and Technology, India
- Council of Scientific and Industrial Research, India
- Indian Institute of Science Education and Research Mohali