Longitudinal clinical and imaging analysis of hydrocephalus in a single-center study in 57 patients with mucopolysaccharidosis type IH (Hurler syndrome)
In patients without preexisting hydrocephalus, no new cases of hydrocephalus developed, and ventricular size stabilized within 2 years after transplant. The authors call into question the overall utility of serial brain MRI after transplant in patients with MPS IH.
Authors
- Carolina Sandoval-Garcia (ORCID: https://orcid.org/0000-0003-1418-3568)
- Shiwei Huang
- Julie B. Eisengart (ORCID: https://orcid.org/0000-0001-5340-017X)
- David Nascene (ORCID: https://orcid.org/0000-0002-2468-7359)
- Troy C. Lund (ORCID: https://orcid.org/0000-0001-9174-8919)
- Paul J. Orchard (ORCID: https://orcid.org/0000-0001-9426-1292)
- Ashish O. Gupta
- Ryan Shanley (ORCID: https://orcid.org/0000-0003-2398-5466)
- Moo‐Yeol Choi
- Daniel Guillaume
Institutions
- University of Minnesota (US)
- University Radiology (US)
Publication Details
- Journal
- Journal of Neurosurgery Pediatrics
- Published
- 2025-05-09
- DOI
- https://doi.org/10.3171/2025.2.peds24476
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00