Cerebrospinal fluid YKL‐40 relates to white matter hyperintensity progression in females but not males over a 6‐year period
·Cerebrospinal fluid YKL-40 is associated with white matter hyperintensities in females but not males cross-sectionally and longitudinally.·Longitudinally, cerebrospinal fluid YKL-40 is associated with white matter hyperintensities in the parietal and temporal lobes, regions that exhibit early pathological changes in Alzheimer's disease .·Cerebrospinal fluid YKL-40 is not associated with white matter microstructural measures.
Authors
- Timothy J. Hohman (ORCID: https://orcid.org/0000-0002-3377-7014)
- T. Bryan Jackson (ORCID: https://orcid.org/0000-0002-6318-1916)
- Niranjana Shashikumar
- Derek B. Archer (ORCID: https://orcid.org/0000-0001-8638-0785)
- Logan C. Dumitrescu (ORCID: https://orcid.org/0000-0002-9782-9944)
- Amalia Jo Peterson (ORCID: https://orcid.org/0000-0002-7015-7957)
- Yunyi Sun
- W Hudson Robb (ORCID: https://orcid.org/0000-0002-8952-7719)
- L. Taylor Davis (ORCID: https://orcid.org/0000-0003-2939-3875)
- Angela Lee Jefferson (ORCID: https://orcid.org/0000-0002-8245-0587)
- Kimberly R. Pechman (ORCID: https://orcid.org/0000-0003-0596-8064)
- Bennett A. Landman (ORCID: https://orcid.org/0000-0001-5733-2127)
- Kaj Blennow
- Henrik Zetterberg (ORCID: https://orcid.org/0000-0003-3930-4354)
- Dandan Liu (ORCID: https://orcid.org/0000-0002-4635-0087)
- Elizabeth E. Moore
- Abigail W. Workmeister
- Hailey A. Adegboye
- Isabella Deberghes
Institutions
- Vanderbilt University (US)
- Sahlgrenska University Hospital (SE)
- UK Dementia Research Institute (GB)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
- Mass General Brigham (US)
- University of Gothenburg (SE)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/dad2.70110
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Vanderbilt University
- Cure Alzheimer's Fund
- Stiftelsen för Gamla Tjänarinnor
- EU Joint Programme – Neurodegenerative Disease Research
- European Partnership on Metrology
- National Institute for Health and Care Research
- University College London
- European Commission
- Hjärnfonden
- Vetenskapsrådet
- UK Dementia Research Institute
- HORIZON EUROPE Framework Programme
- National Institute on Aging
- National Institute of General Medical Sciences
- National Center for Advancing Translational Sciences