Disentangling the effects of sex and gender on <i>APOE</i> ɛ4–related neurocognitive impairment
Apolipoprotein E (<i>APOE</i>) ɛ4 increases neurocognitive impairment (NCI) risk, with a greater impact in females (hazard ratio [HR] = 2.48) than males (HR = 1.96).Sex significantly modifies the effect of <i>APOE</i> ɛ4 on NCI (<i>P</i> < 0.0001f).Femininity score increases NCI risk (HR = 1.07) independently of sex and <i>APOE</i> ɛ4.Understanding the distinct sex and gender contributions to <i>APOE</i> ɛ4-related NCI can improve interventions.
Authors
- Marie‐Christyne Cyr (ORCID: https://orcid.org/0009-0001-1727-4740)
- Amina Barhdadi
- Marie‐Pierre Dubé (ORCID: https://orcid.org/0000-0001-8442-4393)
- Sylvie Provost (ORCID: https://orcid.org/0000-0003-3133-0080)
- Louis Bherer (ORCID: https://orcid.org/0000-0003-2258-8194)
- Louis‐Philippe Lemieux Perreault (ORCID: https://orcid.org/0000-0001-7423-0958)
- Sarah A. Gagliano Taliun (ORCID: https://orcid.org/0000-0003-1306-1868)
- Johanna Sandoval (ORCID: https://orcid.org/0000-0002-7543-2188)
- Marie‐Pierre Sylvestre (ORCID: https://orcid.org/0000-0001-5803-4615)
- Tatiana Dessy (ORCID: https://orcid.org/0000-0003-3203-0530)
- Joëlle Rouleau
Institutions
- Montreal Heart Institute (CA)
- Centre Hospitalier de l’Université de Montréal (CA)
- Université de Montréal (CA)
Publication Details
- Journal
- Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/dad2.70111
- Citations
- 1
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Wellcome Trust
- Cancer Research UK
- British Heart Foundation
- Canada Research Chairs
- Northwest Regional Development Agency
- Canadian Institutes of Health Research
- Fonds de Recherche du Québec - Santé
- Medical Research Council