Association of RDoC dimensions with <i>post mortem</i> brain transcriptional profiles in Alzheimer's disease
<i>Post mortem</i> brain tissue investigations are critically important for Alzheimer's disease (AD) research.Neuropsychiatric symptoms in AD are common and an important aspect of AD.Categorical phenotypes are commonly used, but insufficiently describe the heterogenous presentation of AD.Using natural language processing (NLP) of <i>post mortem</i> brain donor health records provides insight into dimensional phenotypes of AD.We provide evidence for distinct RNA expression profiles associated with NLP-derived Research Domain Criteria clinical domain scores.
Authors
- Jonathan S. Vogelgsang (ORCID: https://orcid.org/0000-0001-9326-8193)
- Peter Durning (ORCID: https://orcid.org/0000-0001-8350-8587)
- Sabina Berretta (ORCID: https://orcid.org/0000-0002-4057-7766)
- Thomas H. McCoy (ORCID: https://orcid.org/0000-0002-5624-0439)
- Torsten Klengel (ORCID: https://orcid.org/0000-0001-7045-9229)
- Dan Shu (ORCID: https://orcid.org/0000-0002-0267-1102)
- Weiqian Jiang
Institutions
- Harvard University (US)
- McLean Hospital (US)
- Massachusetts General Hospital (US)
Publication Details
- Journal
- Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring
- Published
- 2025-04-01
- DOI
- https://doi.org/10.1002/dad2.70103
- Citations
- 3
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.49
Funders
- Alzheimer's Association
- Deutsche Forschungsgemeinschaft
- National Institute on Aging
- National Institute of Mental Health
- National Institute of Child Health and Human Development