Differential roles of human tau isoforms in the modulation of inflammation and development of neuropathology
This new mouse model of tauopathy more completely recapitulates the pattern, severity and accumulation of tau and associated neuropathology and behavioral changes observed in human tauopathies such as AD. 3R/4Rtau-tg bigenic mice should supplant existing single transgenic tau models for general validation of therapeutic targets and investigations of novel therapies on tauopathy endpoints.
Authors
- Dong Yul Sung
- Robert A. Rissman (ORCID: https://orcid.org/0000-0001-9245-8278)
- Brian Spencer (ORCID: https://orcid.org/0000-0002-7486-1941)
- Aaron Schueler
Institutions
- University of Southern California (US)
Publication Details
- Journal
- Neurobiology of Disease
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1016/j.nbd.2025.106942
- Citations
- 1
- Primary Topic
- Alzheimer's disease research and treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- National Institutes of Health
- National Institute on Aging
- National Institute of Neurological Disorders and Stroke