Epithelial cells and fibroblasts are both activated via TGF-β1 and GSK-3β pathways differentially in the comorbidity of pulmonary fibrosis with lung adenocarcinoma
This study initially reveals that LUAD exacerbates PF by modulating epithelial cells and fibroblasts through TGF-β and GSK-3β pathways differentially. Practically, targeting the pathways of TGF-β and GSK-3β may promise a potential strategy for the prophylaxis of PF exacerbation in patients with LUAD.
Authors
- Huanqin Liu
- Aijun Yang (ORCID: https://orcid.org/0000-0002-0447-7493)
- Chenguang Yang (ORCID: https://orcid.org/0000-0001-5255-5559)
- Zijian Qin (ORCID: https://orcid.org/0000-0002-5458-7906)
- Hongyan Guo (ORCID: https://orcid.org/0000-0001-6917-5341)
- Hu Ma (ORCID: https://orcid.org/0000-0002-2921-7815)
- Feng Yang (ORCID: https://orcid.org/0000-0001-9469-4901)
- Fang-Fang Zhang
- Jing Wei (ORCID: https://orcid.org/0000-0001-7457-0688)
- Xiang An (ORCID: https://orcid.org/0009-0004-3167-4072)
- Yamei Dang
- Mengdan Hou
Institutions
- Tarim University (CN)
- Gansu Provincial Hospital (CN)
- First Hospital of Lanzhou University (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Life Sciences
- Published
- 2025-05-09
- DOI
- https://doi.org/10.1016/j.lfs.2025.123696
- Citations
- 2
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 3.04
Funders
- Health Commission of Gansu Province
- National Natural Science Foundation of China
- Natural Science Foundation of Gansu Province
- Science and Technology Department of Gansu Province